South America cruise
Destination

South America Cruises

3,127 sailings · from $70 per person · rates refreshed daily

See departures →
Planning a South America cruise? Get a free quote from a CLIA-accredited advisor.

Next South America departures — page 2 of 8

DepartureShipItineraryLengthFrom portFrom*
Oct 18, 2026 Celebrity Flora 7 Night Galapagos Outer Loop Cruise 7 nights Baltra (Galapagos) on request
Oct 18, 2026 Costa Serena Japan, Taiwan, China, Philippines, Australia, New Caledonia, Fiji, Tonga, Polynesia, Chile, Argentina 65 nights Tokyo (Japan) $9,366
Oct 18, 2026 Costa Serena Japan, Taiwan, China, Philippines, Australia, New Caledonia, Fiji, Tonga, Polynesia, Chile 51 nights Tokyo (Japan) $7,200
Oct 18, 2026 Delfin III From the Inca Empire to the Peruvian Amazon 10 nights Lima, Peru on request
Oct 19, 2026 Aria Amazon Amazon Explorer Cruise 4 nights Iquitos, Peru $5,150
Oct 20, 2026 Silver Endeavour King George Island to King George Island 6 nights King George Island, Antarctica $13,000
Oct 20, 2026 Silver Wind Puerto Williams to King George Island 9 nights Puerto Williams, Chile $10,000
Oct 20, 2026 Aqua Nera Amazon Explorer Cruise 4 nights Iquitos, Peru $7,050
Oct 21, 2026 National Geographic Explorer Patagonia Chilean Fjords and Argentina's Staten 10 nights Santiago, Chile on request
Oct 21, 2026 AmaMelodia Wonders of Colombia 7 nights Cartagena, Colombia on request
Oct 21, 2026 MS Santa Cruz II Galápagos Islands - In Darwin’s Footsteps (Eastern Route) 8 nights Quito $6,695
Oct 21, 2026 MS Santa Cruz II Galápagos Islands – Iconic Wildlife & Sublime Scenery Plus Machu Picchu 11 nights Quito $9,646
Oct 22, 2026 National Geographic Islander II Peru and Galápagos Escape - Lima to Quito 10 nights Lima on request
Oct 22, 2026 MS Santa Cruz II Galápagos Islands - Nine of the Best Isles plus Machu Picchu 15 nights Lima, Peru $13,131
Oct 23, 2026 National Geographic Endeavour II Exploring Galápagos, Machu Picchu and Peru's Land 15 nights Guayaquil, Ecuador $19,580
Oct 23, 2026 National Geographic Endeavour II Exploring Galápagos 9 nights Guayaquil, Ecuador $11,910
Oct 23, 2026 Costa Serena China, Philippines, Australia, New Caledonia, Fiji, Tonga, Polynesia, Chile, Argentina 60 nights Hong Kong $9,079
Oct 23, 2026 Costa Serena China, Philippines, Australia, New Caledonia, Fiji, Tonga, Polynesia, Chile 46 nights Hong Kong $6,613
Oct 23, 2026 National Geographic Delfina Galápagos by Catamaran: An Intimate Voyage 9 nights Guayaquil, Ecuador $22,750
Oct 23, 2026 National Geographic Delfina Galápagos by Catamaran, Machu Picchu and Peru's Land of the Inca 15 nights Quito $30,420
Oct 23, 2026 Aria Amazon Amazon Discovery Cruise 3 nights Iquitos, Peru $3,860
Oct 23, 2026 National Geographic Gemini Exploring Galápagos, Machu Picchu and Peru's Land 15 nights Guayaquil, Ecuador on request
Oct 23, 2026 Delfin III From the Inca Empire to the Peruvian Amazon with the Nazca Lines 12 nights Lima, Peru on request
Oct 24, 2026 Grandeur of the Seas 7 Night Southern Caribbean Cruise 7 nights Colon, Panama on request
Oct 24, 2026 Silver Origin San Cristóbal, Galapagos to San Cristóbal, Galapag 7 nights San Cristóbal, Galapagos $12,250
Oct 24, 2026 AmaMagdalena Wonders of Colombia 7 nights Cartagena, Colombia $3,549
Oct 24, 2026 Aqua Nera Amazon Discovery Cruise 3 nights Iquitos, Peru $5,620
Oct 25, 2026 Grandeur of the Seas 7 Night Southern Caribbean Cruise 7 nights Cartagena, Colombia on request
Oct 25, 2026 Celebrity Flora 7 Night Galapagos Inner Loop Cruise 7 nights Baltra (Galapagos) on request
Oct 25, 2026 Delfin III From the Inca Empire to the Peruvian Amazon 10 nights Lima, Peru on request
Oct 26, 2026 MSC Musica MSC Grand Voyages from Civitavecchia (Rome) 16 nights Civitavecchia (Rome), Italy on request
Oct 26, 2026 MSC Musica MSC Grand Voyages from Civitavecchia (Rome) 17 nights Civitavecchia (Rome), Italy on request
Oct 26, 2026 MSC Musica MSC Grand Voyages from Civitavecchia (Rome) 14 nights Civitavecchia (Rome), Italy on request
Oct 26, 2026 Silver Endeavour King George Island to King George Island 6 nights King George Island, Antarctica $22,900
Oct 27, 2026 MSC Musica MSC Grand Voyages from Genoa (Portofino) 15 nights Genoa (Portofino), Italy on request
Oct 27, 2026 MSC Musica MSC Grand Voyages from Genoa (Portofino) 16 nights Genoa (Portofino), Italy on request
Oct 27, 2026 National Geographic Islander II Galápagos Escape - Roundtrip Quito 7 day 6 nights Guayaquil, Ecuador $11,058
Oct 27, 2026 MS Santa Cruz II Galápagos Islands - Nine of the Best Isles (Western and Northern Route) 10 nights Quito $9,901
Oct 27, 2026 MS Santa Cruz II Galápagos Islands – Iconic Wildlife & Sublime Scenery | Western Route 6 nights Quito $6,416
Oct 28, 2026 MSC Musica MSC Grand Voyages from Marseille 14 nights Marseille (Provence), France on request
Oct 28, 2026 MSC Musica MSC Grand Voyages from Marseille 15 nights Marseille (Provence), France on request
Oct 29, 2026 MSC Musica MSC Grand Voyages from Tarragona 13 nights Tarragona, Spain on request
Oct 29, 2026 National Geographic Explorer Antarctica, South Georgia, and the Falklands 22 nights Buenos Aires on request
Oct 29, 2026 Silver Wind King George Island to Puerto Williams 27 nights King George Island, Antarctica on request
Oct 30, 2026 Nieuw Amsterdam 21-Day Southern Caribbean & Panama Canal: Abc Islands 21 nights Fort Lauderdale $3,544
Oct 30, 2026 Caribbean Princess Panama Canal with Costa Rica & Caribbean 12 nights Fort Lauderdale $919
Oct 30, 2026 L'Austral Callao to Valparaiso 5 nights Callao - Lima (Peru) on request
Oct 30, 2026 National Geographic Resolution Classic Patagonia: Glaciers and Peaks 8 nights Puerto Natales on request
Oct 30, 2026 National Geographic Endeavour II Exploring Galápagos, Machu Picchu and Peru's Land 15 nights Guayaquil, Ecuador $19,575
Oct 30, 2026 National Geographic Endeavour II Exploring Galápagos 9 nights Guayaquil, Ecuador $11,905
Oct 30, 2026 MS Fridtjof Nansen Highlights Of Antarctica 11 nights Ushuaia $8,830
Oct 30, 2026 MS Santa Cruz II Galápagos Islands – In Darwin’s Footsteps Plus Machu Picchu 13 nights Lima, Peru $9,925
Oct 30, 2026 National Geographic Delfina Galápagos by Catamaran: An Intimate Voyage 9 nights Guayaquil, Ecuador $28,196
Oct 30, 2026 National Geographic Delfina Galápagos by Catamaran, Machu Picchu and Peru's Land of the Inca 15 nights Quito $35,866
Oct 30, 2026 Aria Amazon Amazon Expeditions Cruise 7 nights Iquitos, Peru $8,940
Oct 30, 2026 Aria Amazon Amazon Discovery Cruise 3 nights Iquitos, Peru $4,020
Oct 30, 2026 National Geographic Gemini Exploring Galápagos, Machu Picchu and Peru's Land 15 nights Guayaquil, Ecuador on request
Oct 31, 2026 Grandeur of the Seas 7 Night Southern Caribbean Cruise 7 nights Colon, Panama $1,212
Oct 31, 2026 Silver Origin San Cristóbal, Galapagos to San Cristóbal, Galapag 7 nights San Cristóbal, Galapagos $11,900
Oct 31, 2026 Silver Origin San Cristóbal, Galapagos to San Cristóbal, Galapag 14 nights San Cristóbal, Galapagos on request

*Per person, double occupancy, cruise fare from. Taxes and fees may apply. Rates refresh daily — email us for today's exact price.