A Mediterranean cruise packs Rome, Barcelona, the Greek Isles and the French Riviera into a single week. The most common embarkation ports are Barcelona, Rome (Civitavecchia), Athens and Venice — all served by direct flights from major U.S. cities.
MSC, Costa, Royal Caribbean, Norwegian and Celebrity operate most departures. Seven-night Western Mediterranean (Italy, France, Spain) and Eastern Mediterranean (Greece, Croatia, Turkey) loops are the best sellers.
Planning a Mediterranean cruise? Get a free quote from a CLIA-accredited advisor.
Best time to cruise the Mediterranean
The season runs April through November, peaking in July and August. May, June, September and October offer pleasant weather, thinner crowds and better fares.
Next Mediterranean departures
| Departure | Ship | Itinerary | Length | From port | From* |
|---|---|---|---|---|---|
| Sep 30, 2026 | Balmoral | Exploration of the Mediterranean | 71 nights | Southampton, UK | on request |
| Sep 30, 2026 | Balmoral | Islands & Cities of the Mediterranean | 61 nights | Southampton, UK | on request |
| Sep 30, 2026 | Balmoral | Islands & Bays of Italy, Croatia & Greece | 50 nights | Southampton, UK | on request |
| Sep 30, 2026 | Balmoral | Scenic Shores of Italy, Croatia & Greece | 40 nights | Southampton, UK | on request |
| Sep 30, 2026 | Balmoral | Coastal Gems of Spain, Italy & Croatia | 29 nights | Southampton, UK | on request |
| Sep 30, 2026 | Balmoral | Spain & Italy with the Amalfi Coast | 19 nights | Southampton, UK | on request |
| Sep 30, 2026 | Balmoral | Charming Spanish Cities & Autumn Warmth | 8 nights | Southampton, UK | on request |
| Sep 30, 2026 | MSC Grandiosa | 7 nights Western Mediterranean from Civitavecchia (Rome) | 7 nights | Civitavecchia (Rome), Italy | $3,461 |
| Sep 30, 2026 | MSC World Europa | 7 nights Western Mediterranean from La Valletta | 7 nights | La Valletta, Malta | $1,712 |
| Sep 30, 2026 | Sirena | Barcelona to Rome | 12 nights | Barcelona, Spain | $4,199 |
| Sep 30, 2026 | Viking Sky | Italian Sojourn - Rome to Venice | 7 nights | Rome, (Civitavecchia), Italy | $6,499 |
| Sep 30, 2026 | Viking Sky | Adriatic & Mediterranean Sojourn -Rome to Istanbul | 21 nights | Rome, (Civitavecchia), Italy | $19,097 |
| Sep 30, 2026 | Viking Sky | Italy, the Adriatic & Greece - Rome to Athens | 14 nights | Rome, (Civitavecchia), Italy | $12,298 |
| Sep 30, 2026 | Costa Smeralda | Mediterranean from Palma | 7 nights | Palma de Mallorca | on request |
| Sep 30, 2026 | Costa Pacifica | Spain, Italy, France | 6 nights | Valencia | on request |
| Sep 30, 2026 | Costa Diadema | Spain, Portugal, Gibraltar, France, Italy, Morocco | 13 nights | Cadiz (Spain) | on request |
| Sep 30, 2026 | Costa Toscana | Italy, France | 3 nights | Naples | on request |
| Sep 30, 2026 | Costa Pacifica | Spain, Italy, France | 5 nights | Valencia | on request |
| Oct 1, 2026 | Legend of the Seas | 7 Night Western Mediterranean Cruise | 7 nights | Rome (Civitavecchia), Italy | on request |
| Oct 1, 2026 | Azura | Western Mediterranean Fly-Cruise | 7 nights | Valletta, Malta | on request |
| Oct 1, 2026 | Azura | Mediterranean and Canary Islanfly-Cruise | 15 nights | Valletta, Malta | on request |
| Oct 1, 2026 | Azura | Mediterranean and Canary Islanfly-Cruise | 16 nights | Valletta, Malta | on request |
| Oct 1, 2026 | Crystal Serenity | Barcelona to Lisbon | 10 nights | Barcelona, Spain | $8,900 |
| Oct 1, 2026 | MS La Belle De L'Adriatique | Croatia and Montenegro | 7 nights | Dubrovnik | $3,190 |
| Oct 1, 2026 | MSC Musica | Mediterranean from Valencia | 7 nights | Valencia, Spain | on request |
| Oct 1, 2026 | MSC Divina | 7 nights Eastern Mediterranean from Naples (Pompeii) | 7 nights | Naples (Pompeii), Italy | $1,053 |
| Oct 1, 2026 | MSC Orchestra | 7 nights Western Mediterranean from Marseille (Provence) | 7 nights | Marseille (Provence), France | $710 |
| Oct 1, 2026 | MSC Seaview | 7 nights Western Mediterranean from Barcelona | 7 nights | Barcelona | $976 |
| Oct 1, 2026 | MSC Splendida | 7 nights Western Mediterranean from Palermo (Monreale) | 7 nights | Palermo (Monreale), Italy | $992 |
| Oct 1, 2026 | Wind Spirit | Treasures of the Greek Isles | 7 nights | Piraeus, Athens | on request |
| Oct 1, 2026 | Celebrity Equinox | 9 Night Spain, Portugal & Morocco | 9 nights | Barcelona, Spain | $2,556 |
| Oct 1, 2026 | MS Adriatic Sky | Split, Zadar and Secrets of the North Yacht Cruise | 7 nights | Split | on request |
| Oct 1, 2026 | Le Champlain | Ancient civilisations, from Italy to Greece | 10 nights | Civitavecchia, Rome, Italy | on request |
| Oct 1, 2026 | Le Boreal | Authentic Mediterranean shores | 9 nights | Valletta, Malta | on request |
| Oct 1, 2026 | Costa Toscana | Italy, France, Spain | 7 nights | Civitavecchia, Italy | $892 |
| Oct 1, 2026 | Costa Smeralda | Italy, France, Spain, Balearic Islands | 7 nights | Palermo (Sicily) | $1,181 |
| Oct 1, 2026 | Costa Smeralda | Italy, France, Spain | 4 nights | Palermo (Sicily) | $1,102 |
| Oct 1, 2026 | Costa Toscana | Italy, France | 2 nights | Civitavecchia, Italy | $387 |
| Oct 2, 2026 | Arcadia | Eastern Mediterranean Discovery | 19 nights | Southampton | on request |
| Oct 2, 2026 | MSC Meraviglia | 7 nights Western Mediterranean from Palermo (Monreale) | 7 nights | Palermo (Monreale), Italy | $2,660 |
| Oct 2, 2026 | MSC Divina | 7 nights Eastern Mediterranean from Civitavecchia (Rome) | 7 nights | Civitavecchia (Rome), Italy | $1,244 |
| Oct 2, 2026 | MSC Seaview | 7 nights Western Mediterranean from Marseille (Provence) | 7 nights | Marseille (Provence), France | $1,043 |
| Oct 2, 2026 | MSC Splendida | 7 nights Western Mediterranean from La Valletta | 7 nights | La Valletta, Malta | $852 |
| Oct 2, 2026 | MSC Fantasia | 9 nights Eastern Mediterranean from Bari | 9 nights | Bari, Italy | $1,621 |
| Oct 2, 2026 | MSC Grandiosa | 7 nights Western Mediterranean from Palma de Mallorca (Baleari Is.) | 7 nights | Palma de Mallorca, Spain | $1,069 |
| Oct 2, 2026 | MSC World Europa | 7 nights Western Mediterranean from Barcelona | 7 nights | Barcelona | $705 |
| Oct 2, 2026 | Mein Schiff 2 | Faszination Mittelmeer - ab/bis Palma | 7 nights | Palma (Mallorca) | on request |
| Oct 2, 2026 | Mein Schiff 5 | Inselperlen des Mittelmeers mit Athen und Istanbul | 14 nights | Heraklion | on request |
| Oct 2, 2026 | Mein Schiff 2 | Schönheiten des westlichen Mittelmeers - ab/bis Pa | 14 nights | Palma (Mallorca) | on request |
| Oct 2, 2026 | Mein Schiff 5 | Inseln des östlichen Mittelmeers | 7 nights | Heraklion | on request |
| Oct 2, 2026 | Seven Seas Navigator | Istanbul to Rome (Civitavecchia) | 14 nights | Istanbul | $19,849 |
| Oct 2, 2026 | Celebrity Constellation | 10 Night Best Of Italy & Croatia Cruise | 10 nights | Ravenna, Italy | $1,273 |
| Oct 2, 2026 | Celebrity Xcel | 10 Night Italy & French Riviera | 10 nights | Barcelona, Spain | $2,018 |
| Oct 2, 2026 | Celestyal Discovery | Iconic Greek Islands - 3Nights | 3 nights | Athens (Lavrion), Greece | $469 |
| Oct 2, 2026 | Viking Sea | Mediterranean & Adriatic Odyssey Athens (Piraeus) to Rome (Civitavecchia) | 14 nights | Athens (Piraeus), Greece | $8,999 |
| Oct 2, 2026 | Carnival Legend | Mediterranean from Civitavecchia (Rome), Italy | 9 nights | Civitavecchia (Rome) | $845 |
| Oct 2, 2026 | Costa Smeralda | Italy, France, Spain, Balearic Islands | 7 nights | Civitavecchia, Italy | $912 |
| Oct 2, 2026 | Costa Toscana | Italy, France, Spain | 7 nights | Genoa, Italy | $940 |
| Oct 3, 2026 | Explorer of the Seas | 7 Night Greek Isles Cruise | 7 nights | Ravenna, Italy | $954 |
| Oct 3, 2026 | Liberty of the Seas | 7 Night Spain & France Cruise | 7 nights | Southampton, England | $1,545 |
*Per person, double occupancy, cruise fare from. Taxes and fees may apply. Rates refresh daily — email us for today's exact price.
Cruise lines sailing to the Mediterranean
Frequently asked questions
When is the best time for a Mediterranean cruise?
The season runs April through November, peaking in July and August. May, June, September and October offer pleasant weather, thinner crowds and better fares.
Where do Mediterranean cruises depart from?
Main embarkation ports include Southampton, UK, Civitavecchia (Rome), Italy, La Valletta, Malta, Barcelona, Spain, Rome, (Civitavecchia), Italy .
How much does a Mediterranean cruise cost?
Fares vary by ship, cabin and date; current sailings start around $69 per person, double occupancy. Rates refresh daily — request a quote for an exact price.